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MKNK2

MAP kinase-interacting serine/threonine-protein kinase 2 is a protein in humans that is encoded by MKNK2 gene. Serine/threonine-protein kinase that phosphorylates SFPQ/PSF, HNRNPA1 and EIF4E. May play a role in the response to environmental stress and cytokines. Appears to regulate translation by phosphorylating EIF4E, thus increasing the affinity of this protein for the 7-methylguanosine-containing mRNA cap. Required for mediating PP2A-inhibition-induced EIF4E phosphorylation. Triggers EIF4E shuttling from cytoplasm to nucleus. Isoform 1 displays a high basal kinase activity, but isoform 2 exhibits a very low kinase activity. Acts as a mediator of the suppressive effects of IFNgamma on hematopoiesis. Negative regulator for signals that control generation of arsenic trioxide As(2)O(3)-dependent apoptosis and anti-leukemic responses. Involved in anti-apoptotic signaling in response to serum withdrawal.

MKNK2 Antibodies

MKNK2 Proteins

MKNK2 Proteins for Rattus norvegicus (Rat)

MKNK2 Proteins for Xenopus tropicalis (Western clawed frog) (Silurana tropicalis)

MKNK2 Proteins for Xenopus laevis (African clawed frog)

MKNK2 Proteins for Mus musculus (Mouse)

MKNK2 Proteins for Homo sapiens (Human)



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