f RecombinantHumanGrowth/differentiationfactor6(GDF6)生长因子专业提供基因,重组【优德线上娱乐场】蛋白,w88优德体育手机app登录:抗体,ELISAkit,诊断试剂原料,定制服务_w88手机版登录 RecombinantHumanGrowth/differentiationfactor6(GDF6)生长因子专业提供基因,重组【优德线上娱乐场】蛋白,w88优德体育手机app登录:抗体,ELISAkit,诊断试剂原料,定制服务_w88手机版登录

优德亚洲平台

Recombinant Human Growth/differentiation factor 6(GDF6)

In Stock
  • 货号:
    CSB-AP005971HU
  • 规格:
    ¥9822
  • 图片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

优德亚洲平台

  • 纯度:
    > 95 % as determined by SDS-PAGE and HPLC analyses.
  • 内毒素:
    Less than 0.1 EU/ug as determined by LAL method.
  • 生物活性:
    Fully biologically active when compared to standard. The ED50 as determined by inducing alkaline phosphatase production of murine ATDC5 cells is less than 2.0 μg/ml, corresponding to a specific activity of > 500 IU/mg.
  • 基因名:
    GDF6
  • Uniprot No.:
  • 别名:
    GDF6; BMP13; GDF16Growth/differentiation factor 6; GDF-6; Bone morphogenetic protein 13; BMP-13; Growth/differentiation factor 16
  • 种属:
    Homo sapiens (Human)
  • 【优德线上娱乐场】蛋白长度:
    Full Length of Mature Protein
  • 来源:
    E.Coli
  • 分子量:
    13.6 kDa
  • 表达区域:
    336-455aa
  • 氨基酸序列
    TAFASRHGKR HGKKSRLRCS KKPLHVNFKE LGWDDWIIAP LEYEAYHCEG VCDFPLRSHL EPTNHAIIQT LMNSMDPGST PPSCCVPTKL TPISILYIDA GNNVVYKQYE DMVVESCGCR
  • 【优德线上娱乐场】蛋白标签:
    Tag-Free
  • 产品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液:
    Lyophilized from a 0.2 um filtered concentrated solution in 30 % Acetonitrile and 0.1 % TFA.
  • 储存条件:
    Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

靶点详情

  • 功能:
    Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map
  • 基因功能参考文献:
    1. findings indicate that increased BMP signaling owing to a GDF6 gain-of-function mutation is responsible for loss of joint formation and profound functional impairment in patients with Multiple Synostoses Syndrome 4. PMID: 26643732
    2. As fetal age increased, the expression of growth differentiation factor 6 was decreased correspondingly with the progress of ossification in vertebral bodies and restricted to cartilaginous regions. PMID: 26184900
    3. BMP13 has a role in enhancing extracellular matrix accumulation and inducing cell migration in certain intervertebral disc cells PMID: 26134557
    4. GDF6 is overexpressed in Leri's pleonosteosis. PMID: 24442880
    5. There was a possible weak association between the rs6982567 near GDF6 and polypoidal choroidal vasculopathy in this replication study with an independent Han Chinese cohort. PMID: 25416513
    6. Deficiency of gdf6 results in photoreceptor degeneration, so demonstrating a connection between Gdf6 signaling and photoreceptor survival. PMID: 23307924
    7. a critical role of HTRA1 in the regulation of angiogenesis via TGF-beta signaling and identified GDF6 as a novel disease gene for AMD. PMID: 22049084
    8. studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers PMID: 21702718
    9. induces ligamentogenic differentiation in mesenchymal progenitors PMID: 20334610
    10. Observational study of gene-disease association. (HuGE Navigator) PMID: 20734064
    11. These data suggest a potential role for BMP-13 (the human homologue to GDF-6) in tendon matrix modeling and/or remodeling. PMID: 19492402
    12. Observational study of gene-disease association. (HuGE Navigator) PMID: 20494911
    13. The spectrum of disorders generated by morpholino inhibition and the more severe defects (microphthalmia and anophthalmia) observed at higher doses illustrate the key role of GDF6 in ocular development. PMID: 17236135
    14. Mutation screening of a large and clinically diverse Klippel-Feil syndrome (KFS) cohort has identified GDF6 missense mutations in both familial and sporadic KFS patients. PMID: 18425797
    15. These data establish the important role of growth differentiation factor 6 in ocular and vertebral development. PMID: 19129173
    16. BMP-13 inhibited osteogenic differentiation of bone marrow multipotent mesenchymal stromal cells, implying that functional mutations or deficiency of BMP-13 may allow excess bone formation PMID: 19240811
    17. Observational study of gene-disease association. (HuGE Navigator) PMID: 20057906
    18. Observational study of gene-disease association. (HuGE Navigator) PMID: 18716610

    显示更多

    收起更多

  • 相关疾病:
    Klippel-Feil syndrome 1, autosomal dominant (KFS1); Microphthalmia, isolated, 4 (MCOP4); Leber congenital amaurosis 17 (LCA17)
  • 亚细胞定位:
    Secreted
  • 【优德线上娱乐场】蛋白家族:
    TGF-beta family
  • 数据库链接:

    HGNC: 4221

    OMIM: 118100

    KEGG: hsa:392255

    STRING: 9606.ENSP00000287020

    UniGene: Hs.492277



千赢国际qy88.vⅰp+qy88.vipmanbetxapp优德亚洲平台beplay3下载